Tag

4PL.

Every dispatch tagged 4PL. Evidence status and limitations are stated in each article.

Dose-responseSep 8, 20265 min

Why your IC50 curve fit fails

Troubleshoot incomplete dose-response curves, normalization, outliers, and constraints, with a reproducible example of relative versus absolute IC50.

Simulated inhibitory curve showing a restricted concentration range and distinct relative and absolute 50-percent endpoints

Δ vs paper

Worked example

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Standard curvesSep 8, 20264 min

4PL vs. 5PL curve fitting: how to choose

Compare 4PL and 5PL standard curves using residuals and back-calculated concentrations, with downloadable simulated data and a reproducible Python script.

Simulated asymmetric calibration standards with 4PL and 5PL fitted curves and residuals

Δ vs paper

Worked example

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Dose-responseUpdated Sep 8, 20263 min

Dose-response illustration: evidence correction

This article previously presented a generated illustration as evidence of an analysis. The comparison claims have been withdrawn pending verification of the original inputs and outputs.

Simulated dose-response illustration; not a captured experimental analysis

Δ vs paper

Correction

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